Blar i forfatter "Njølstad, Inger"

Viser treff 1-20 av 103

    • Achievements of primary prevention targets in individuals with high risk of cardiovascular disease: an 8-year follow-up of the Tromsø study 

      Hagen, Amalie Nilsen; Ariansen, Inger Kristine Holtermann; Hanssen, Tove Aminda; Lappegård, Knut Tore; Eggen, Anne Elise; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)
      Aims To study change over 8 years in cardiovascular risk, achievement of national guideline-based treatment targets of lipids, blood pressure (BP) and smoking in primary prevention of cardiovascular disease (CVD), medication use, and characteristics associated with target achievement among individuals with high CVD risk in a general population.<p> <p>Methods and results We followed 2524 women ...

    • Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium 

      Morseth, Bente; Geelhoed, Bastiaan; Linneberg, Allan; Johansson, Lars; Kuulasmaa, Kari; Salomaa, Veikko; Iacoviello, Licia; Constanzo, Simona; Söderberg, Stefan; Niiranen, Teemu; Vishram, Julie K.K.; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Zeller, Tanja; Blankenberg, Stefan; Ojeda, Francisco; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      <p><i>Background:</i> The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age. <p><i>Methods:</i> We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from ...

    • Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study 

      Di Castelnuovo, Augusto; Costanzo, Simona; Bonaccio, Marialaura; McElduff, Patrick; Salomaa, Veikko; Männistö, Satu; Moitry, Marie; Ferrières, Jean; Dallongeville, Jean; Thorand, Barbara; Brenner, Hermann; Ferrario, Marco; Veronesi, Giovanni; Pettenuzzo, Emanuela; Tamosiunas, Abdonas; Njølstad, Inger; Drygas, Wojciech; Nikitin, Yuri; Söderberg, Stefan; Kee, Frank; Grassi, Guido; Westermann, Dirk; Schrage, Benedikt; Dabboura, Salim; Zeller, Tanja; Kuulasmaa, Kari; Blankenberg, Stefan; Donati, Maria Benedetta; de Gaetano, Giovanni; Iacoviello, Licia (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Aim To test the association of alcohol consumption with total and cause-specific mortality risk. Design Prospective observational multi-centre population-based study. Setting Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. Participants A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). Measurements Average alcohol intake by ...

    • Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption : an individual-level prescription database study 

      Sakshaug, Solveig; Hartz, Ingeborg; Furu, Kari; Skurtveit, Svetlana; Engeland, Anders; Eggen, Anne Elise; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-12-05)
      Background: A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. Our objective was to explore how differences in prevalences of use, dosing characteristics, choice of statin and continuity of therapy in individual patients adds new information ...

    • Association between diastolic dysfunction and future atrial fibrillation in the Tromsø Study from 1994 to 2010 

      Tiwari, Sweta; Schirmer, Henrik; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Heggelund, Geir; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-13)
      Objective. To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods. We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. ...

    • Association between neighborhood health behaviors and body-mass index in Northern Norway: Evidence from the Tromsø Study 

      SARI, Emre; Moilanen, Mikko; Bambra, Clare; Grimsgaard, Sameline; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Aim: The prevalence of overweight and obesity has risen rapidly worldwide, and the ongoing obesity pandemic is one of the most severe public health concerns in modern society. The average body mass index (BMI) of people living in Northern Norway has also steadily increased since the late 1970s. This study aimed to understand how individuals’ health behavior is associated with the general health ...

    • Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium 

      Sinning, Christoph; Makarova, Nataliya; Völzke, Henry; Schnabel, Renate B.; Ojeda, Francisco; Dörr, Marcus; Felix, Stephan B.; Koenig, Wolfgang; Peters, Annette; Rathmann, Wolfgang; Schöttker, Ben; Brenner, Hermann; Veronesi, Giovanni; Cesana, Giancarlo; Brambilla, Paolo; Palosaari, Tarja; Kuulasmaa, Kari; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Blankenberg, Stefan; Söderberg, Stefan; Ferrario, Marco M.; Thorand, Barbara (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-15)
      Background: Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) is used to monitor the quality of diabetes treatment. Its strength of association with cardiovascular outcomes in the general population remains uncertain. This study aims to assess the association of HbA<sub>1c</sub> with cardiovascular outcomes in the general ...

    • Association of iron deficiency with incident cardiovascular diseases and mortality in the general population 

      Schrage, Benedict; Rübsamen, Nicole; Ojeda, Francisco; Thorand, Barbara; Peters, Annette; Koenig, Wolfgang; Söderberg, Stefan; Söderberg, Maja; Mathiesen, Ellisiv B.; Njølstad, Inger; Kee, Frank; Linneberg, Allan; Kuulasmaa, Kari; Palosaari, Tarja; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Karakas, Mahir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Aims - Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.<p> <p>Methods and results - In 12 164 individuals from three European population-based ...

    • Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015 

      Løchen, Maja-Lisa; Gram, Inger Torhild; Mannsverk, Jan T.; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Objectives: <br> There is a shift in the smoking population from daily smokers to light or occasional smokers. The knowledge about possible adverse health effects of this new smoking pattern is limited. We investigated smoking habits with focus on occasional smoking in relation to total mortality in a follow-up study of a Norwegian general population. <br> Setting: <br> A population study ...

    • Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study 

      Solomon, Terry; Smith, Erin N.; Matsui, Hiroko; Brækkan, Sigrid Kufaas; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Frazer, Kelly A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
      Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated ...

    • Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...

    • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

      Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
      <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...

    • Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study 

      Enga, Kristin Fjeldstad; Rye Holmboe, Ina; Mathisen Hald, Erin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study 

      Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Arntzen, Kjell Arne; Ball, Jocasta; Stewart, Simon; Wilsgaard, Tom; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
      Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...

    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...

    • Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016 

      Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Nilsen, Amalie; Njølstad, Inger; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)
      Background: <br> Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and ...

    • Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study 

      Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger; Heiss, G (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
      Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). <p>Methods: The health metric score was derived from ideal ...

    • CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study 

      Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-01)
      Objective:<br> CHA2DS2-VASc score, left atrial (LA) size and atrial fibrillation (AF) have individually been associated with stroke risk. Our aim was to investigate the predictive ability of combinations of these factors for the odds of incident stroke in a population-based cohort study.<br> Methods:<br> We followed 2844 participants from the Tromsø Study from 1994 to 2012. Information on LA size ...

    • Change in cardiovascular risk assessment tool and updated Norwegian guidelines for cardiovascular disease in primary prevention increase the population proportion at risk: The Tromsø Study 2015-2016 

      Nilsen, Amalie; Hanssen, Tove Aminda; Lappegård, Knut Tore; Eggen, Anne Elise; Løchen, Maja-Lisa; Selmer, Randi Marie; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-30)
      Aims - To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year risk of both fatal and non-fatal risk of CVD and the Norwegian national guidelines from 2017.<p> <p>Methods - We included participants ...

    • Cohort Profile : Cohort of Norway (CONOR) 

      Arnesen, Egil; Næss, Øyvind; Søgaard, Anne Johanne; Njølstad, Inger; Beckstrøm, Anne Cathrine; Bjertness, Espen; Engeland, Anders; Hjort, Peter F; Holmen, Jostein; Magnus, Per; Tell, Grethe S.; Vatten, Lars; Vollset, Stein Emil; Aamodt, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)